Hey! If you're interested in running a TTRPG themed around Homestuck, you can find information and a link to my game Tablestuck on the front page of this website! Even if you want to stick to DnD, it might serve as a good source of inspiration to how you might approach homebrewing it. Outside of Tablestuck, there are also a few other cool Homestuck TTRPGs I've seen in the community, like RPGstuck which is made by some very cool people.